EXPLORING THE INSULIN SECRETORY PROPERTIES OF THE PGD2-GPR44/DP2 AXIS IN VITRO AND IN A RANDOMIZED PHASE-1 TRIAL OF TYPE 2 DIABETES PATIENTS.

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

AIMS/HYPOTHESIS:GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets.In rodent islets, PGD2 is produced in response to glucose, arcade smokey the bear belt suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia.Consequent

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How pollinator visits are affected by flower damage and ants presence in Ipomoea carnea subs. fistulosa (Martius and Choise) (Convolvulaceae)?

Abstract This study aimed to evaluate the effects of florivory and of the patrolling ants associated to EFNs-extrafloral nectaries, on the frequency of floral visitors, using the specie Ipomoea carnea Canvas Mesh Athletic Running Shoes subs.fistulosa (Martius and Choise) in Caatinga area.The floral attributes of the species were characterized.The e

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Comparative Analysis of the Development of Acquired Radioresistance in Canine and Human Mammary Cancer Cell Lines

Research using in vitro canine mammary cancer cell lines and naturally-occurring canine mammary tumors are not only fundamental models used to advance the understanding of cancer in veterinary patients, but are also regarded as excellent translational models of human breast cancer.Human breast cancer is commonly treated with radiotherapy; however,

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