Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.
AIMS/HYPOTHESIS:GPR44 (DP2, PTGDR2, CRTh2) is the receptor for the pro-inflammatory mediator prostaglandin D2 (PGD2) and it is enriched in human islets.In rodent islets, PGD2 is produced in response to glucose, arcade smokey the bear belt suggesting that the PGD2-GPR44/DP2 axis may play a role in human islet function during hyperglycemia.Consequent